Managing digital assets across multiple blockchains has become essential for crypto users, from DeFi enthusiasts to long-term investors. A cross-chain wallet with Ledger support offers the perfect blend of security, interoperability, and user control—ensuring private keys remain offline while enabling seamless interactions across decentralized networks.
In this guide, we explore the top 10 cross-chain wallets that integrate with Ledger hardware devices, combining non-custodial security with multi-chain functionality. These wallets empower users to manage diverse portfolios, stake assets, trade across chains, and interact with decentralized applications (dApps) without compromising safety.
What Makes a Cross-Chain Wallet Secure?
Before diving into the list, it’s important to understand what sets these wallets apart:
- Ledger Integration: Ensures private keys are stored offline, protecting against online threats.
- Non-Custodial Architecture: Users retain full control over their funds.
- Multi-Chain Support: Enables asset management across Ethereum, Binance Smart Chain, Polygon, and more.
- DeFi & Staking Access: Direct integration with protocols for earning yield and swapping tokens.
- Minimal KYC: Prioritizes privacy and decentralization.
👉 Discover how secure wallet integration boosts your crypto safety and control.
1. Hana Wallet
Hana Wallet stands out as a powerful multi-chain DeFi wallet with robust support for both the ICON network and EVM-compatible blockchains. Its seamless Ledger integration ensures that users can interact with DeFi protocols while keeping private keys securely offline.
Ideal for those navigating multiple ecosystems, Hana enables direct access to staking, token swaps, and dApp interactions—all without sacrificing control or security.
Key Features:
- Ledger Support: Yes – secure key storage via hardware wallet
- Cross-Chain Compatibility: ICON + EVM chains (e.g., Ethereum, BSC, Polygon)
- Security: Non-custodial with end-to-end encryption
- DeFi Access: Integrated access to leading DeFi platforms
- Staking Support: Earn rewards on supported assets
Hana is particularly valuable for users invested in the ICON ecosystem who also want exposure to broader EVM-based opportunities.
2. DeFi Wallet
As its name suggests, DeFi Wallet is purpose-built for decentralized finance. It supports multiple blockchains and integrates smoothly with Ledger, making it a go-to choice for users focused on earning yields through staking and liquidity provision.
The wallet’s intuitive interface simplifies complex DeFi operations like yield farming and cross-chain swaps—ideal for both beginners and advanced users.
Key Features:
- Ledger Support: Yes – hardware-backed private key protection
- Cross-Chain Compatibility: Ethereum, Binance Smart Chain, Polygon, and others
- Staking Support: Built-in staking for major cryptocurrencies
- Asset Management: Unified dashboard for multi-chain holdings
- Privacy-Focused: Minimal KYC requirements
With strong security and deep DeFi integration, DeFi Wallet bridges usability and functionality.
3. MyEtherWallet (MEW)
One of the original Ethereum wallets, MyEtherWallet (MEW) remains a trusted option for managing ETH and ERC-20 tokens. Its full Ledger compatibility ensures enterprise-grade security, while its open-source nature fosters transparency.
MEW supports Ethereum Layer 2 networks like Arbitrum and Optimism, expanding its utility beyond the base chain.
Key Features:
- Ledger Support: Yes – full hardware wallet integration
- Cross-Chain Compatibility: Ethereum + EVM-compatible Layer 2s
- NFT & Token Management: View and transfer NFTs directly
- DeFi Access: Connects to top dApps like Uniswap and Aave
- Staking Support: Participate in Ethereum 2.0 staking
👉 Learn how integrating hardware wallets enhances your DeFi experience.
MEW is especially useful for Ethereum-centric investors who value self-custody and broad ecosystem access.
4. Zerion
Zerion combines portfolio tracking with wallet functionality, offering a unified view of assets across Ethereum, Polygon, Arbitrum, Avalanche, and other major chains. With Ledger support, users maintain security while gaining powerful analytics tools.
Its clean interface makes it easy to swap tokens, supply liquidity, or monitor performance—all within one app.
Key Features:
- Ledger Support: Yes – secure transaction signing
- Cross-Chain Compatibility: Over 10+ blockchains supported
- Portfolio Tracking: Real-time balance updates and performance metrics
- DeFi Aggregation: Access to lending, borrowing, and yield opportunities
- User Experience: Designed for active traders and long-term holders alike
Zerion excels as a DeFi portfolio manager, ideal for users juggling multiple positions across chains.
5. MetaMask
No list of cross-chain wallets is complete without MetaMask, the most widely used Web3 wallet. While originally Ethereum-focused, MetaMask now supports any EVM-compatible chain through custom RPC configuration.
Its browser extension and mobile app make dApp browsing effortless, and Ledger integration adds an essential layer of security.
Key Features:
- Ledger Support: Yes – via USB or Bluetooth
- Cross-Chain Compatibility: All EVM chains (BSC, Polygon, Fantom, etc.)
- Token Swaps: In-wallet swapping powered by aggregators
- NFT Support: Full NFT viewing and transfer capabilities
- Developer-Friendly: Standard tool for Web3 developers
MetaMask is best suited for users deeply embedded in the Ethereum ecosystem or those exploring various EVM-based projects.
6. Paradex
Paradex functions as both a decentralized exchange (DEX) and a cross-chain wallet with native Ledger support. It enables peer-to-peer trading directly from the wallet interface without requiring users to deposit funds into a third-party contract.
This non-custodial model enhances security while allowing efficient cross-chain asset swaps.
Key Features:
- Ledger Support: Yes – secure signing for trades
- Cross-Chain Trading: Swap assets across different networks
- No Deposit Required: Trade directly from your wallet
- Low Fees: Optimized routing reduces transaction costs
- DeFi Access: Integrated DEX functionality
Paradex is perfect for traders who prioritize control and want to avoid centralized exchange risks.
7. Guarda Wallet
Guarda is a multi-asset wallet supporting over 50 blockchains, including Bitcoin, Ethereum, Solana, and Cardano. Its Ledger integration ensures that even with broad support, security remains uncompromised.
Additional features like in-wallet staking and atomic swaps enhance its versatility.
Key Features:
- Ledger Support: Yes – hardware-backed transactions
- Cross-Chain Compatibility: Extensive network coverage
- Staking Support: Earn rewards on multiple PoS coins
- Exchange Functionality: Swap tokens without leaving the app
- No Registration Required: Truly non-custodial
Guarda is ideal for users managing diverse portfolios across non-EVM and EVM chains.
8. MyEOSWallet
Focused on the EOS blockchain, MyEOSWallet provides seamless Ledger integration for secure management of EOS tokens and NEP-5 assets. It supports staking, voting in governance, and dApp interaction—all while keeping keys offline.
Though primarily EOS-centric, it offers limited cross-chain features.
Key Features:
- Ledger Support: Yes – secure key handling
- EOS Staking & Voting: Participate in network consensus
- dApp Integration: Access EOS-based games and services
- User-Friendly Interface: Simple navigation for new users
This wallet is a top pick for EOS community members seeking hardware-grade security.
9. Firefly Wallet
Developed by the IOTA Foundation, Firefly Wallet is the official wallet for the IOTA network. It supports Ledger integration and allows users to stake IOTA tokens (via Shimmer) and participate in network governance.
Its focus on the Tangle ledger technology sets it apart from traditional blockchain wallets.
Key Features:
- Ledger Support: Yes – secure signing for IOTA transactions
- IOTA & Shimmer Support: Native handling of both ecosystems
- Staking Support: Delegate IOTA to earn rewards
- Energy-Efficient Design: Reflects IOTA’s eco-friendly ethos
Firefly is essential for anyone invested in the IOTA ecosystem.
10. Neon Wallet
Neon Wallet is the premier choice for NEO blockchain users. It supports Ledger integration, enabling secure storage and management of NEO and NEP-5 tokens.
It also provides access to NEO-based dApps and staking rewards through GAS generation.
Key Features:
- Ledger Support: Yes – full hardware compatibility
- NEO Staking: Earn GAS passively
- dApp Browser: Explore decentralized apps on NEO
- Simple UI: Clean design for easy use
Neon Wallet delivers reliable security and functionality for the NEO community.
Frequently Asked Questions (FAQ)
Q: Why should I use a cross-chain wallet with Ledger support?
A: Combining a cross-chain wallet with Ledger ensures you maintain full control of your private keys while securely managing assets across multiple blockchains—offering both flexibility and top-tier protection.
Q: Are these wallets truly non-custodial?
A: Yes—all listed wallets are non-custodial, meaning only you control your private keys. Ledger integration further enhances this by storing keys offline.
Q: Can I stake crypto directly through these wallets?
A: Most of them—such as DeFi Wallet, Zerion, Guarda, and Neon—offer built-in staking features that allow you to earn passive income directly from the app.
Q: Do I need technical knowledge to use these wallets?
A: Not necessarily. While some wallets cater to advanced users (like Zerion), many—including MetaMask and Guarda—are designed with intuitive interfaces suitable for beginners.
Q: Is KYC required?
A: No. All wallets listed here require minimal or no KYC, preserving user privacy and aligning with decentralized principles.
👉 Explore how leading wallets integrate with hardware devices for maximum security.
Final Thoughts
Choosing the right cross-chain wallet with Ledger support comes down to your specific needs—whether you're focused on DeFi, NFTs, staking, or multi-chain trading. From versatile options like Zerion and MetaMask to ecosystem-specific tools like Firefly and Neon Wallet, each offers a unique balance of security, functionality, and ease of use.
By leveraging Ledger’s hardware-level protection, these wallets ensure your digital assets remain safe—even as you explore the evolving world of Web3.